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Uvax Bio, Inc.

 

 

 

Business: Vaccines targeting infectious diseases.

 

Industry/Market: $47B in current annual worldwide sales of existing approved vaccines with $20B predicted for 2021 in sales for COVID-19 vaccines alone. Traditionally a relatively small segment of the overall biopharmaceutical industry, vaccines and their role in meeting emergent health challenges have recently been underscored in importance, and it is likely the trend will increase with unprecedented global attention.

 

Status: Uvax Bio has a robust pipeline of more than nine vaccine candidates ready to advance to clinical trials including COVID-19, HIV, RSV, HCV, Ebola, Influenza, Lassa, Malaria, and Tuberculosis.

 

 

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The proprietary technology is licensed from The Scripps Research Institute. Our paradigm-shifting 1c-SApNP (single-component self-assembling protein nanoparticle) vaccine platform combines structure-based optimization of antigens with nanoparticle engineering and consists pf three integrated components:

 

(i) An Optimized Antigen (UvaxAG) that elicits a strong protective immune response.

 

(ii) A protein nanoparticle (pNP) that displays 20 of the optimized antigens in precise geometry, contains structural and functional helper elements, and is engineered to a size that is easily recognized by the human immune system.

 

(iii) A one-for-all bio-manufacturing process enabled by a single-component (1c) that genetically encodes the entire vaccine particle.

 

 

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The most-advanced vaccine candidate, UvaxAg I3-01 is undergoing CMC-manufacturing and IND-enabling studies. A pre-IND meeting is anticipated by the end of 2020 with first-in-human planned for 2Q2021. Uvax Bio has partnered with Abzena (San Diego, CA) for CMC-manufacture and ICON plc (Dublin, Ireland) to support the IND-preparation and filing.

 

 

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$15M in NIH grants to Scripps Research supported discovery and early research for HIV-1, HCV, SARS (now SARS-CoV-1), and MERS vaccine candidates.

 

 

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Two allowed and five pending patents covering specific target antigen designs and the platform technology filed by The Scripps Research Institute (TSRI) and licensed to Uvax Bio with global and sublicense rights.

 

 

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$17M combined seed and pre-IPO funding in convertible debt.

 

Management:

 

 

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Ji Li, PhD. CEO, President, & Co-Founder.

 

 

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Mark Blomquist. Chief Financial Officer.

 

 

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Linling He, PhD. Executive Vice President & Chief Technical Officer.

 

 

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John Moroney. Executive Vice President of Business Development.

 

 

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Colette Saccomanno, PhD, MSLIS. Senior Vice President of Corporate Affairs.

 

Scientific Advisory Board:

 

 

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Jiang Zhu, PhD, Chair of the Scientific Advisory Board, Co-Founder & Co-Inventor. Professor, Departments of Immunology & Microbiology and Integrative Structure & Computational Biology, The Scripps Research Institute, La Jolla, CA.

 

 

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Ian Wilson, DPhil. Professor & Chair, Department of Integrative Structure & Computational Biology, The Scripps Research Institute, LaJolla, CA.

 

 

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Drew Weismann, MD, PhD. Professor & Chair, Department of Integrative Medicine, Perelman School of Medicine of the University of Pennsylvania.

 

 

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Robin Shattock, PhD. Professor & Head of Mucosal Infection & Immunity, Department of Medicine, Imperial College of London.

 

Offering: Pre-IPO financing.

 

Website

 

Offices: 3801 Kennett Pike, Suite A101, Wilmington, DE 19807-9998

 

Contact: Ji Li, PhD, CEO/President. 302.364.0363 or ji.li@ufovax.com

 

 

 

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